The new EurOPDX Research Infrastructure (RI), funded by the European Union Horizon 2020 programme, aims to improve cancer drug development success rates through the enablement of collaborative cancer research using patient-derived xenograft (PDX) models. In particular, we are developing efficient and user-friendly IT tools to optimise access to, and data searching of the collection of PDX models and their clinical, molecular and pharmacological annotations. We will be presenting the EurOPDX RI and the possibilities of access to PDX models, as well as the functionalities of the EurOPDX Data Portal, with the objective to support future applicants to our PDX access grant programme.