Tutorial

Epigenetics - Hi-C analysis of Drosophila melanogaster cells using HiCExplorer

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DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Questions of the tutorial:

  • Why is a Hi-C analysis useful?
  • What is 'chromosome conformation capture'?
  • What are main steps in order to generate and plot a Hi-C contact matrix?

Resource type: Tutorial

Authors: joachimwolff, fidelram, vivekbhr, polkhe

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