Safe-and-Sustainable-by-Design (SSbD) advanced materials and chemicals (AdMas&Chems) are a central requirement for reaching the ambitious goal of making Europe the first digitally-enabled circular, climate-neutral and sustainable economy. Such new AdMas&Chems need to provide the high functionality required for their advanced applications, whilst simultaneously exhibiting improved safety and sustainability performances that take into account the complete value chain and life cycle, as outlined in the SSbD framework proposed by the EU Joint Research Centre and adopted in the Commission Recommendation of 8 Dec. 2022. To facilitate adoption by industry and, by doing so, foster the twin green and digital transition of Europe’s economy, PINK’s overarching aim is to produce innovative modelling software and integrated workflows for the development of AdMas&Chems, which are combined into an industry-ready open innovation platform, the PINK In Silico Hub (PINKISH).